Contact Details

Dr Roger Phillips

Reader in Cancer Pharmacology
R.M.Phillips@bradford.ac.uk

Tel/ext: +44 (0) 1274 235367
Fax: +44 (0) 1274 233234

PhD (Bradford), BSc (Wales)

Tumour microenvironment as a target for therapeutic intervention with a specific interest in bioreductive pro-drugs.
Design and evaluation of novel bioreductive drugs
Analysis of tumour enzymology
Impact that various polymorphic variants of key drug metabolising enzymes on drug activation processes and tumour biology
Development of experimental models tailored for the evaluation of molecules in this class, particularly the use of multicell spheroids for both drug evaluation and target identification.
Tumour bioenergetics as a target for drug development

M Volpato and R M Phillips, "Tailoring targeted therapy to individual patients: lessons to be learnt from the development of Mitomycin C," Review article submitted to Cancer Genomics and Proteomics, 4; 175-186, 2007
A Evans, V Bates, H Troy, S Hewitt and S Holbeck, Y-Li Chung, R M Phillips, M Stubbs, J Griffiths and R Airley, "Glut-1 as a therapeutics target: increased chemoresistance and HIF-1 independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies," Cancer Chemotherapy and Pharmacology, in press
R Puri, V Palit, PM Loadman, M Flannigan, T Shah, GA Choudry, S Basu, JA Double, G Lenaz , S Chawla, M Beer, C Van Kalken, R de Boer, JH Beijnen, CJ Twelves and RM Phillips. Phase I/II pilot study of intravesical Eoquin (EO9) against superficial bladder cancer. J Urol 2006.
A Nicolaou, V Pavillard, JA Double, RM Phillips. .Methionine dependence of tumours: A biochemical strategy for optimizing Paclitaxel chemosensitivity in vitro. Biochem Pharmacol 71; 772-778, 2006.
R E Airley, RM Phillips, Andrew Evans, J Double, AM Burger, HH Feibig, CML West, IJ Stratford. Hypoxia-regulated Glucose Transporter Glut-1 May Influence Chemosensitivity to Some Alkylating Agents: Results of EORTC (First Translational Award) Study of the Relevance of Tumour Hypoxia to the Outcome of Chemotherapy in Human Tumour-Derived Xenografts. Int J Oncol 26: 1477-84, 2005

Mohammed Saleem (Joint supervision with Dr K Pors) PhD project: Therapeutic strategies for enhancing the efficacy of chemotherapy by manipulating the Warbug effect.
Toufic Khalil (Joint supervision with Dr K Pors) PhD project: Investigation of anticancer agents in multicellular cancer models.
H Evans (Joint supervision with Dr Wheelhouse) PhD project: Identifying and Drugging an New Anti-tumour Target. Funded by Yorkshire Cancer Research. Award expected in 2009.
H Makin (Joint supervision with Dr Loadman) PhD project: Quantitative cancer therapeutics; from model to clinic. Funded by Yorkshire Cancer Research. Award expected in 2010.
S Adekunle (Joint supervision with Dr S Parkin) MPhil project: Evaluation of telomerase as a marker of disease in patients with throat cancer. Funded by Bradford NHS Trust. Award expected in 2008.

Course co-ordinator for MSc in Cancer Pharmacology
Module leader for Toxicology and Oncology (Biomedical Sciences)
Various contributions to teaching on other modules including; research and analytical methods, molecular basis of disease and biological and organic chemistry.
Membership of academic committees and board of examiners.

British Association for Cancer Research (former executive committee member)
American Association of Cancer Research
Editor for British Journal of Pharmacology (Reviews)
Referee for various academic journals, grants and external examining of post-graduate students.
EORTC-PAMM drug development committee member